3^rd International Conference on Hepatobiliary & Pancreatic Disorders September 17-18, 2018 | Philadelphia, Pennsylvania, USA

Pancreas is one of the master chemists of the body that produce hormones exocrine and endocrine to assist in the digestion of food. It consists of different types of pancreatic cells. The exocrine cells include acinar cells and the endocrine cells are present in clusters of cells called the islets of Langerhans. The Islets of Langerhans function ith the help of pancreatic alpha, beta, delta and gamma cells. The gall bladder is small sac-shaped organ beneath the liver, in which bile is stored after secretion by the liver and before release into the intestine. Genetic screening studies have helped identify gene mutations that lead to pancreatic diseases and in identifying the changes in the pancreatic cells affected by diseases.

Hepato-biliary diseases include liver diseases and biliary diseases. Their study is known as hepatology.

Pancreatic diseases include acute and chronic pancreatitis characterized by severe inflammation of the pancreas. Pancreatitis may also be classified as hereditary pancreatitis and necrotizing pancreatitis. Other disorders of the pancreas include endocrine and exocrine syndromes, Zollinger-Ellison syndrome. Pancreatic divisum is congenital disorder where the pancreas is not joint but is present as two or three different parts.

Liver disease (also called hepatic disease) is a type of damage to or disease of the liver.

Intraductal papillary mucinous neoplasm (IPMN) is a kind of tumor (neoplasm) that develops inside the pancreatic ducts and is portrayed by the creation of thick liquid by the tumor cells Intraductal papillary mucinous neoplasms are vital in light of the fact that in the event that they are left untreated some of them advance to obtrusive disease (change from a favorable tumor to a harmful tumor). Similarly as colon polyps can form into colon growth if left untreated, so too do some ntraductal papillary mucinous neoplasms advance into an intrusive pancreatic malignancy. Intraductal papillary mucinous neoplasms can exhibit a chance to treat a pancreatic tumor before it forms into a forceful, difficult to-treat disease. Intraductal papillary mucinous neoplasm (IPMN) is a kind of tumor (neoplasm) that develops inside the pancreatic ducts and is portrayed by the creation of thick liquid by the tumor cells Intraductal papillary mucinous neoplasms are vital in light of the fact that in the event that they are left untreated some of them advance to obtrusive disease (change from a favorable tumor to a harmful tumor). Similarly as colon polyps can form into colon growth if left untreated, so too do some intraductal papillary mucinous neoplasms advance into an intrusive pancreatic malignancy. Intraductal papillary mucinous neoplasms can exhibit a chance to treat a pancreatic tumor before it forms into a forceful, difficult to-treat disease.

Canine Pancreatitis is inflammation of the pancreas that can occur in two very different forms. Acute pancreatitis is sudden while chronic pancreatitis is characterized by recurring or persistent form of pancreatic inflammation. Cases of both can be considered mild or severe.

There are a variety of disorders of the pancreas including acute pancreatitis, chronic pancreatitis, hereditary pancreatitis, and pancreatic cancer. Acute pancreatitis may be a single or a recurring event, and it usually occurs suddenly. The abdominal pain with acute pancreatitis is often severe. Chronic pancreatitis is characterized by chronic or persistent abdominal pain and may or may not present with raised pancreatic enzymes. Cancer of the pancreas is the fourth leading cause of cancer death in the United States, killing more than 39,000 people a year. Risks include smoking, age, sex (more common in men), chronic pancreatitis, and exposure to some industrial chemicals.

Surgery is often part of the treatment for pancreatic cancer if it can be done. Depending on the type and stage of your cancer, surgery might be used to remove the cancer and part or your entire pancreas. Ablation or embolization is another way of destroying the tumors without surgery. Anti cancer drugs are either introduced by injecting into the veins or by oral administration. Chemotherapy and Radiation therapy are sometimes used simultaneously. Whipple procedures are surgical removal of cancerous pancreatic parts. This also includes pancreaticoduodenectomy and pylorous preserving whipple.

Purinergic signalling is the extra cellular actions of the cells in which ATP is used as a neuro transmitter to send fast signals. In pancreas these signals are used in both exocrine and endocrine functions to send signals to the central nervous system. Studies have found that these signals are used in all functions of all cells including cancers.

In this session we will discuss the various pathological conditions responsible for the irregular functioning of the pancreas, physical testing for any masses in the pancreas, blood tests to determine the content of pancreatic enzymes like amylase and lipase, resulting conditions such as infection, anemia and indigestion. Predominantly, these are the tests prescibed for initial diagnosis The Pancreas blood tests, secretin stimulation test and fecal elastase test.

Pancreatic Cancer and the various diseases associated with this organ have been in the top priority of most researchers in the field of research. In the near past, the number of people dying of pancreatic cancer and its various diseases had increased to an extent that currently, it has become the fourth most common cause of Cancer Death in the United States. Researchers have been focussed on finding advanced treatment techniques for this cancer type. Including high alcoholism, there are number of causes that lead to malfunction or disrupt the normal metabolism of this organ.

Replacing of diseased pancreas with a healthy pancreas is pancreatic transplantation. Different transplant methods include Pancreas Alone Transplant, Liver-Pancreas Transplant, Pancreas after Kidney Transplant and Simultaneous Kidney Pancreas Transplant. Islet Cell Transplantation involves only the transplantation of Islet cells. Care is taken that the grafts are accepted with the help of immunosuppressant and new anesthesia techniques.

Hepatobiliary and pancreatic disorders are some of the commonest disorders of the digestive system. The hepatopancreatobiliary system has a complex embryological development and therefore is subject to anomalies that may sometimes have deleterious implications on the body physiology, besides being associated with a spectrum of acquired problems that require specialized training to tackle surgically. Gallstone disease is one of the most prevalent gastrointestinal diseases with a substantial burden on the health care system. Pathogenesis is multifactorial and prevalence has increased in recent years amongst all segments of society probably due to changes in life style, alteration in dietary patterns, altered physical activity.

Positron emission tomography (PET) Scan is done to image the area of cancer by injecting radioactive sugars. Magnetic Resonance Cholangiopancreatography (MRCP) is used to look at the pancreas. This test is not used for biopsies. Endoscopic Retrograde Cholangiopancreatography (ERCP) is used to check for pancreatic cancer and any blocks by injecting a dye through endoscopy. This test can also be used for biopsies. Endoscopic ultrasound is done with a small ultrasound probe attached to endocope. Biopsy is most commonly done by laparoscopy. Trans abdominal ultrasound examination is used to detect cancers and stones in the gall bladder. Case reports of such diagnosis and clinical trials will be discussed in this session.

Purinergic signalling is the extra cellular actions of the cells in which ATP is used as a neuro transmitter to send fast signals. In pancreas these signals are used in both exocrine and endocrine functions to send signals to the central nervous system. Studies have found that these signals are used in all functions of all cells including cancers.

Pancreatic cancer is the fourth leading cause of cancer deaths, being responsible for 7% of all cancer-related deaths in both men and women. Approximately 75% of all pancreatic carcinomas occur within the head or neck of the pancreas, 15-20% occurs in the body of the pancreas, and 5-10% occurs in the tail. Scientists are learning more about some of the changes in DNA that cause cells in the pancreas to become cancerous. Inherited changes in genes such as BRCA2, p16, and the genes responsible for hereditary non-polyposis colorectal cancer (HNPCC) can increase a person’s risk of developing pancreatic cancer.