Jose Mario F De Oliveira
Universidad Federal Fluminense, Brazil
Biography
Albeit diagnosed and defined as a “sugar disease of the adult”; i.e., namely a disease of the carbohydrate metabolism by mostly authors; So called type 2 diabetes mellitus should be better defined as a “No Man’s Land” state of disease in adults, at most diagnosed by, in the majority of cases, a fasting glycemia equal or higher than 126 mg/dL. And Why That? Because in a global epidemic, which is badly out of control, there is not much time to lose. So let’s get into some facts! Despite all controversies surrounding the etiology, pathogenesis, and therapeutic roles for hyperglycemia in type 2 diabetes mellitus, newer anti-hyper-glycemic drugs are still getting onto the market at a high speed, due to the overconfidence in HbA1c as a surrogate outcome for micro-vascular complications; albeit. All large recent randomized clinical trials and meta-analysis have shown that trying to achieve glycemic levels close to the normal range did not reduce the most clinically important micro-vascular or macro-vascular hard endpoints as end-stage renal disease, vision loss, cardiovascular and total mortality, with the added harm of substantial increase in the number of hypoglycemic episodes, and even death rates. Is it not too soon for us to forget about the rosiglitazone saga? The above, among other core issues, will be covered in our talk.
Abstract
Abstract : What it is and what it is not - Type 2 diabetes mellitus