Jose Mario F De Oliveira
Universidad Federal Fluminense, Brazil
Title: What are the roles of ace-inhibitors and angiotensin receptor blockers in adult diabetics with hypertension or chronic kidney diseases?
Biography
Biography: Jose Mario F De Oliveira
Abstract
Albeit ACE-Is or ARBs have an undoubtful clinical benefit in diabetic and non-diabetic heart failure, their role as first line drug therapies in type 2 diabetics with hypertension or chronic kidney diseases have been recently put into question despite their – mild - anti-proteinuric effects, both as anti-hypertensive or as renoprotective agents specially in type 2 diabetes mellitus subjects. Angiotensin II, the main octapeptide “defence” molecule and “effector” of the renin-angiotensin-aldosterone system (RAS) has a variety of homeostatic actions in states of health and disease like regulating the salt and potassium balance for blood preesure homeostasis, keeping up the glomerular filtration rate under normal values and modulating the sympathetic nervous system, All in conditions of hypovolemia or salt depletion in order to keep our systemic – blood pressure - renal hemodynamics, and salt balance in good shape. In our Talk, we intend to show the most recent randomised clinical trial and observational evidences about how to deal with these drugs in the various clinical scenarios of diabetics, with and without chronic kidney diseases in order to keep our homeostasis in the right direction.