Howard J Leonhardt
PancreaCell-Leonhardt Ventures Co., USA
Title: Total pancreas regeneration with bioelectric controlled protein expression and micro infusion pump stem cell composition delivery
Biography
Biography: Howard J Leonhardt
Abstract
Our team has developed a pancreas regeneration system with three major components. (1) A micro bioelectric regeneration stimulator that controls release of 10 regeneration promoting proteins including SDF-1 a stem cell homing signal, IGF-1, HGF, EGF, activin A+B, eNOS, VEGF, follistatin and tropoelastin. (2) A programmable, re-fillable micro infusion pump. (3) A proprietary fifteen component stem cell based regeneration composition comprised of a variety of cell types, growth factors, BMP-7, PDLI-1, HGH, selected alkaloids, micro RNAs, nutrient hydrogel, NADA and pancreatic matrix. The stimulator+pump is implanted just below the skin with a re-fillable silicone septum port with pacing infusion lead directed to the pancreas with a total conductive infusion wrap tip that is gentle on the pancreatic tissue. One portion of the lead is directed to the interior portion of the pancreas. Initial pilot translational study data will be presented as well as the anticipated upcoming clinical trial design.