Sripathi M Sureban
Assistant Professor
University of Oklahoma
USA
Biography
Dr. Sripathi M Sureban, at the University of Oklahoma Health Sciences Center, initially as a postdoctoral fellow and now as assistant professor of research, expanded his research to identify, isolate and characterize stem cells of intestine, pancreas, colon and stomach. In collaboration with Dr. Houchen, demonstrated that DCLK1 (formerly known as DCAMKL-1) is upregulated in various cancers including colorectal, pancreas, breast liver and prostate. DCLK1 regulates various tumor suppressor miRNAs, which in turn regulates key oncogenes and transcription factors regulating epithelial to mesenchymal transition (EMT), pluripotency, angiogenesis and metastasis. Currently he is working towards elucidating the mechanism by which RNA binding protein Musashi-1 (Msi-1) regulates tumor growth. It has been demonstrated by his group that Msi-1 is upregulated in colorectal cancer and siRNA mediated knockdown leads to colorectal tumor xenograft growth arrest in immunocompromised mice by inhibiting cancer cell proliferation and inducing mitotic catastrophe. Furthermore, they have recently found that Msi-1 regulates key tumor suppressor miRNAs like Let-7a, miR-144 and miR-200a. These tumor suppressor miRNAs are known to regulate oncogene c-Myc, KRAS, Notch-1 and EMT transcription factors. Our research is also focused on developing nanoparticle formulations for effective delivery of siRNA against Msi-1.
Research Interest
miRNAs in Pancreatic Cancer